Research
The aim of the Sarah Jennifer Knott Foundation Research Award is to inspire and motivate innovation in cancer of unknown primary research.
Research
The aim of the Sarah Jennifer Knott Foundation Research Award is to inspire and motivate innovation in cancer of unknown primary research.
€44,400 research grant awarded to Dr Manel Esteller of the world-renowned Josep Carreras Institute, Barcelona to support his research in CUP using precision medicine, the CUPP-On project. Dr Manel Esteller is regarded as one of the most influential cancer researchers in the world according to classification by Stanford University.
The CUPP-On project pursues to identify actionable genetic or pathway alterations that could guide the use of available target therapies, opening new avenues to support a revolutionary paradigm shift in CUP clinical management.
€60,000 research grant awarded to Dr Esteller for the CUP study- ST- CUP. The aim is to ‘identify novel therapeutic opportunities in CUPs by studying the spatial transcriptome, integrating histology with massive RNA sequencing.
Manel Esteller (Sant Boi de Llobregat, Barcelona, Catalonia, Spain, 1968) graduated in Medicine from the University of Barcelona in 1992, where he also obtained his PhD degree specialising in molecular genetics of endometrial carcinoma, in 1996. He was an Invited Researcher at the School of Biological and Medical Sciences at the University of St. Andrews, (Scotland, UK) during which time his research interests focused on the molecular genetics of inherited breast cancer. From 1997 to 2001, Esteller was a Postdoctoral Fellow and a Research Associate at the Johns Hopkins University and School of Medicine, (Baltimore, USA) where he studied DNA methylation and human cancer. His work was decisive in establishing promoter hypermethylation of tumour suppressor genes as a common hallmark of all human tumours.
€50,000 research grant awarded to St Vincent’s Hospital, Dublin to support an “SJK CUP Research study”. The purpose of this study is to enable CUP patients to be tested with genomic profiling, with results to be shared and discussed at a molecular tumour board.
St.Vincent’s University Hospital (SVUH) is one of the world’s leading academic teaching hospitals providing front line, acute, chronic and emergency care across over 50 different medical specialities.
We are recognised worldwide for setting standards of excellence in clinical diagnosis and treatment, education and research and a pioneering, multi-disciplinary approach to patient care. We are the only public hospital in Ireland with international accreditation.
Our Emergency Department (ED) is the major referral centre for the region for patients with strokes and major trauma. We are home to a number of national centres including the National Centre for Cystic Fibrosis, National Cancer Control Programme (NCCP), National Liver Transplant Programme and the recently established National Pancreas Transplant Programme.
€44,400 research grant awarded to Dr Manel Esteller of the world-renowned Josep Carreras Institute, Barcelona to support his research in CUP using precision medicine, the CUPP-On project. Dr Manel Esteller is regarded as one of the most influential cancer researchers in the world according to classification by Stanford University.
The CUPP-On project pursues to identify actionable genetic or pathway alterations that could guide the use of available target therapies, opening new avenues to support a revolutionary paradigm shift in CUP clinical management.
€60,000 research grant awarded to Dr Esteller for the CUP study- ST- CUP. The aim is to ‘identify novel therapeutic opportunities in CUPs by studying the spatial transcriptome, integrating histology with massive RNA sequencing.
Manel Esteller (Sant Boi de Llobregat, Barcelona, Catalonia, Spain, 1968) graduated in Medicine from the University of Barcelona in 1992, where he also obtained his PhD degree specialising in molecular genetics of endometrial carcinoma, in 1996. He was an Invited Researcher at the School of Biological and Medical Sciences at the University of St. Andrews, (Scotland, UK) during which time his research interests focused on the molecular genetics of inherited breast cancer. From 1997 to 2001, Esteller was a Postdoctoral Fellow and a Research Associate at the Johns Hopkins University and School of Medicine, (Baltimore, USA) where he studied DNA methylation and human cancer. His work was decisive in establishing promoter hypermethylation of tumour suppressor genes as a common hallmark of all human tumours.
€50,000 research grant awarded to St Vincent’s Hospital, Dublin to support an “SJK CUP Research study”. The purpose of this study is to enable CUP patients to be tested with genomic profiling, with results to be shared and discussed at a molecular tumour board.
St.Vincent’s University Hospital (SVUH) is one of the world’s leading academic teaching hospitals providing front line, acute, chronic and emergency care across over 50 different medical specialities.
We are recognised worldwide for setting standards of excellence in clinical diagnosis and treatment, education and research and a pioneering, multi-disciplinary approach to patient care. We are the only public hospital in Ireland with international accreditation.
Our Emergency Department (ED) is the major referral centre for the region for patients with strokes and major trauma. We are home to a number of national centres including the National Centre for Cystic Fibrosis, National Cancer Control Programme (NCCP), National Liver Transplant Programme and the recently established National Pancreas Transplant Programme.
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