€44,400 research grant awarded to Dr Manel Esteller of the world-renowned Josep Carreras Institute, Barcelona to support his research in CUP using precision medicine, the CUPP-On project. Dr Manel Esteller is regarded as one of the most influential cancer researchers in the world according to classification by Stanford University.
The CUPP-On project pursues to identify actionable genetic or pathway alterations that could guide the use of available target therapies, opening new avenues to support a revolutionary paradigm shift in CUP clinical management.
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€60,000 research grant awarded to Dr Esteller for the CUP study- ST- CUP. The aim is to ‘identify novel therapeutic opportunities in CUPs by studying the spatial transcriptome, integrating histology with massive RNA sequencing.
Manel Esteller (Sant Boi de Llobregat, Barcelona, Catalonia, Spain, 1968) graduated in Medicine from the University of Barcelona in 1992, where he also obtained his PhD degree specialising in molecular genetics of endometrial carcinoma, in 1996. He was an Invited Researcher at the School of Biological and Medical Sciences at the University of St. Andrews, (Scotland, UK) during which time his research interests focused on the molecular genetics of inherited breast cancer. From 1997 to 2001, Esteller was a Postdoctoral Fellow and a Research Associate at the Johns Hopkins University and School of Medicine, (Baltimore, USA) where he studied DNA methylation and human cancer. His work was decisive in establishing promoter hypermethylation of tumour suppressor genes as a common hallmark of all human tumours.